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临床所用噻吗心安的立体异构体是S-对映体(l-噻吗心安),它为一种非特异性β-肾上腺素能阻滞剂,是治疗青光眼的一种有效局部用药。虽然很多β-肾上腺素能阻滞剂都能降低眼内压,但l-噻吗心安在青光眼治疗中尤为成功,因其作用时间长、发生耐药性小,且无局部麻醉及拟交感特性。纵使局部用药,仍可能有足量的药物到达全身,影响人体各处的β-肾上腺素能受体。因此局部用/噻吗心安,可产生副作用,尤其对于由β-肾上腺素能阻滞起全身不良情况的病人,如哮喘、充血性心力衰竭的病人。曾有
The clinically used stereoisomer of timolol is the S-enantiomer (l-timolol), a non-specific beta-adrenergic blocker and an effective topical agent for the treatment of glaucoma. Although many beta-adrenergic blockers reduce intraocular pressure, l-timolol is particularly successful in the treatment of glaucoma because of its long duration of action, low resistance, and no local anesthetic and sympathetic properties . Even if topical, there may still be sufficient amount of drug to reach the body, affecting the body’s β-adrenergic receptors. Therefore, local / timolol, can have side effects, especially in patients with systemic diseases due to β-adrenergic blockade, such as asthma, congestive heart failure patients. Have