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目的探讨氧化应激指标在妊娠合并甲状腺功能减退症(妊娠甲减)中的变化。方法妊娠甲减患者120例均分为两组:A组伴有其他合并症,包括妊娠期糖尿病32例、子痫前期15例、先兆早产和早产13例;B组无其他妊娠合并症。选择同期甲状腺功能正常且无合并症的孕妇60例作为对照(C组)。检测三组孕妇超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)和过氧化氢酶(CAT),比较其差异。结果与C组比较,A、B组血浆SOD、GSH-Px降低,MDA增高(P<0.05);A组的改变较B组更为明显(P<0.05)。A组血浆CAT较B、C组增高(P<0.05)。结论妊娠甲减患者,尤其出现合并症时其氧化应激水平增高;氧化应激可能参与妊娠甲减的发生发展。
Objective To investigate the changes of oxidative stress in pregnancy with hypothyroidism (pregnancy hypothyroidism). Methods 120 cases of pregnancy hypothyroidism were divided into two groups: group A with other complications, including 32 cases of gestational diabetes mellitus, preeclampsia 15 cases, threatened premature delivery and premature delivery in 13 cases; B no other pregnancy complications. 60 pregnant women with normal thyroid function and no complications in the same period were selected as control group (group C). The levels of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and catalase (CAT) in pregnant women were measured and compared. Results Compared with group C, the plasma levels of SOD and GSH-Px in group A and group B were significantly lower than those in group C (P <0.05). The changes in group A were more obvious than those in group B (P <0.05). Plasma CAT of group A was higher than that of group B and C (P <0.05). Conclusion Pregnancy hypothyroidism, especially in the case of complications, its oxidative stress increased; oxidative stress may be involved in the occurrence and development of pregnancy hypothyroidism.