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目的:探讨肾母细胞瘤过表达基因(NOV)对肾透明细胞癌分级、分期、大小、增殖状态和预后的影响。方法:应用免疫组化法检测54例肾透明细胞癌组织NOV蛋白的表达,分析其与肾透明细胞癌分期、分级、大小、Ki-67指数的相关性,并比较NOV阳性组和阴性组的生存率差异。结果:NOV在肾脏透明细胞癌组织中的染色强度明显低于癌旁正常肾组织,22例(100%)癌旁正常肾组织均呈强阳性染色,54例肾癌组织中24例(44.4%)为弱阳性染色,8例(14.8%)为中等阳性染色;癌组织总阳性率(59.3%)亦显著低于癌旁正常肾组织(100%),P<0.05。NOV阳性组的Ki-67指数(2.6±1.5)%,明显低于NOV阴性组的(4.2±2.1)%,P<0.05。NOV表达与肿瘤分期及大小无相关性,P>0.05。NOV阳性组术后5年特异生存率(82.6%)显著高于阴性组(50.3%),P<0.05。结论:NOV对肾透明细胞癌起抑制作用,可作为预后判断的肿瘤标志。
Objective: To investigate the effect of over-expression of nephroblastoma (NOV) on the classification, staging, size, proliferation and prognosis of renal clear cell carcinoma. Methods: The expression of NOV protein in 54 cases of clear cell renal cell carcinoma was detected by immunohistochemistry. The correlation between the expression of NOV protein and the stage, grade, size and Ki-67 index of renal clear cell carcinoma was analyzed. The NOV positive group and negative group Differences in survival. Results: The staining intensity of NOV in renal clear cell carcinoma tissues was significantly lower than that in adjacent normal tissues. Twenty-two cases (100%) of adjacent normal renal tissues showed strong positive staining. Among 54 cases of renal cell carcinoma, 24 cases (44.4% ), And 8 (14.8%) were moderately positive staining. The total positive rate of cancer tissues (59.3%) was also significantly lower than that in normal adjacent tissues (100%), P <0.05. The Ki-67 index of NOV positive group (2.6 ± 1.5)% was significantly lower than that of NOV negative group (4.2 ± 2.1)%, P <0.05. There was no correlation between NOV expression and tumor stage and size (P> 0.05). The 5-year specific survival rate (82.6%) in NOV positive group was significantly higher than that in negative group (50.3%), P <0.05. Conclusion: NOV can inhibit renal clear cell carcinoma and can be used as a tumor marker for prognosis.