Spectral and Mechanistic Studies of the Reactions of Substituted 1,5-Benzothiazepine with Dichloroac

• 出 处: Chinese Chemical Letters
• 发表日期: 2001年10期
• 关键词: moiety lactam imine skeleton react steric benzene ortho halide physiological

A [2+2] cycloaddition adduct 2 and a novel ring-opening product 3 were obtained from the reactions of 2,3-benzothiazepines 1 with dichloroacetyl chloride and triethylamine. The relative ratios of 2 and 3 were affected by the addition order of reactants and reaction temperature. The structures were determined by spectral data and the reaction mechanisms for the formation of 2 and 3 were elucidated.

A [2 + 2] cycloaddition adduct 2 and a novel ring-opening product 3 were obtained from the reactions of 2,3-benzothiazepines 1 with dichloroacetyl chloride and triethylamine. The relative ratios of 2 and 3 were affected by the addition order of reactants and reaction temperature. The structures were determined by spectral data and the reaction mechanisms for the formation of 2 and 3 were elucidated.