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Objective: To evaluate the quality of life (QOL) in patients with chronic hepatitis B (CHB) and analyze its correlation with traditional Chinese medicine (TCM) syndrome types. Methods: With cross-sectional investigation adopted, the QOL of 335 CHB patients was studied by the World Health Organization Quality of Life BREF Questionnaire (WHOQOL-BREF) and the chronic liver disease questionnaire (CLDQ). The results was compared with that of 30 healthy persons. Results: The QOL of the patients with chronic hepatitis B was lower than the healthy persons with significant difference between them (P<0.01). Also it was different in patients of different TCM syndrome types (P<0.05 or P<0.01). The lowest QOL was shown in patients of the blood-stasis patients is lower than of healthy persons and closely correlated with TCM syndrome types.