论文部分内容阅读
目的:了解结核病短程化疗方案的药物不良反应发生情况及其对结核病防治工作的影响.对象与方法:回顾性调查了使用2HRZE/4HR、2HRZES/4HRE短程化疗方案的1394例涂阳肺结核病患者.结果:不良反应发生率为28.26%;患者性别、年龄、用药种类、强化期长短,对不良反应均有影响;主要不良反应有胃肠道反应25.05%、过敏反应20.24%、关节损害16.28%、中枢神经症状13.65%和肝损害2.68%等;各药物副反应发生率分别为Z 20.24%、R19.12%、H 15.26%、E 12.63%、S4.68%.结论:由于短化方案药物剂量偏大,不良反应发生率较高,对结防工作有一定的负面影响.建议在方案实施过程中,加强不良反应的监测与处理.
OBJECTIVE: To understand the incidence of adverse drug reactions and its impact on tuberculosis prevention and control in tuberculosis short-term chemotherapy regimen.Methods: A total of 1394 smear positive pulmonary tuberculosis patients treated with 2HRZE / 4HR and 2HRZES / 4HRE short-course chemotherapy were retrospectively reviewed. Results: The incidence of adverse reactions was 28.26%. The gender, age, type of medication, duration of enhancement and adverse reactions were all affected. The main adverse reactions were gastrointestinal reaction (25.05%), anaphylactic reaction (20.24%), joint damage (16.28% 13.65% of central nervous system symptoms, and 2.68% of liver damage. The incidence rates of side effects of each drug were Z 20.24%, R19.12%, H 15.26%, E 12.63%, S4.68%, respectively.Conclusion: The incidence of adverse reactions is high, which has a certain negative impact on the work of preventing and fighting the floods.It is suggested that the monitoring and treatment of adverse reactions should be strengthened during the implementation of the plan.