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白细胞减少是恶性肿瘤病人放疗、化疗中的大难题,同时也是苯作业工人、放射线工作者及临床多种疾病治疗过程中经常遇到的问题。过去常用的某些升高白细胞药物在预防和治疗白细胞减少方面效果并不理想。中国医学科学院药物研究所从细叶小檗(Berberis poiretii)的根中及用细叶小檗提取黄连素的废弃母液中均分离得到一种白色结晶性生物碱成分,经化学鉴定证明均为小檗胺(berbamine),并经药理研究和动物实验证明小檗胺确有刺激造血功能和升高末梢血中白细胞的作用,并对由于抗癌药环磷酰胺引起的大鼠和狗的白细胞减少不仅有治疗作用,还有与环磷酰胺抗癌疗效
Leukopenia is a major problem for radiotherapy and chemotherapy in patients with malignant tumors, and is also a common problem encountered by benzene workers, radiologists and the clinical treatment of various diseases. Some of the commonly used elevated white blood cell drugs in the prevention and treatment of leukopenia effect is not satisfactory. Institute of Materia Medica, Chinese Academy of Medical Sciences from the Berberis poiretii (Berberis poiretii) roots and berberine extract with berberine extracted mother liquor were isolated from a white crystalline alkaloids, the chemical identification were berbamine (berbamine ), And pharmacological studies and animal experiments show that berbamine does stimulate hematopoietic function and increase the role of leukocytes in peripheral blood, and on the anticancer drug cyclophosphamide in rats and dogs not only have a therapeutic effect of leukopenia , As well as cyclophosphamide anticancer efficacy