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目的观察盐酸帕洛诺司琼在预防和治疗乳腺癌FAC或AC方案化疗中出现的消化道不良反应的有效性。方法将50例接受FAC或AC方案化疗的乳腺癌患者随机分成两组,化疗前实验组静脉缓慢注射盐酸帕洛诺司琼0.25mg,对照组静脉缓慢注射盐酸格拉司琼3mg止吐。观察二者对患者化疗后出现的急性呕吐、延迟性呕吐等不良反应的控制情况并做比较。结果实验组和对照组化疗后对急性呕吐(24小时内)止吐效果相近,差异无显著性(94.56%vs.91.28%,P>0.05);实验组中对化疗后出现的延迟性呕吐(24小时～7天)止吐效果明显优于对照组,2组有显著差异性(89.26%vs.60.97%,P<0.05)。结论盐酸帕洛诺司琼能有效控制乳腺癌FAC或AC方案化疗中出现的急性呕吐、延迟性呕吐、恶心。
Objective To observe the effectiveness of palonosetron hydrochloride in the prevention and treatment of gastrointestinal adverse reactions in FAC or AC regimen of breast cancer. Methods Fifty patients with breast cancer undergoing chemotherapy with FAC or AC were randomly divided into two groups. Before the chemotherapy, the rats in the experimental group were injected slowly with 0.25% palonosetron hydrochloride intravenously and the control group with 3 mg granisetron hydrochloride intravenously. To observe the two patients after the treatment of acute vomiting, delayed vomiting and other adverse reactions control and make a comparison. Results The antiemetic effect of acute vomiting (within 24 hours) in experimental group and control group after chemotherapy was similar (94.56% vs.91.28%, P> 0.05). In the experimental group, delayed vomiting 24 hours to 7 days) antiemetic effect was significantly better than the control group, two groups were significantly different (89.26% vs.60.97%, P <0.05). Conclusion Palonosetron hydrochloride can effectively control acute vomiting, delayed vomiting and nausea in breast cancer patients treated with FAC or AC regimen.