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目的：观察乙型肝炎病毒（ＨＢＶ）与戊型肝炎病毒（ＨＥＶ）重叠感染对ＨＢＶ复制的影响。方法：以血清ＨＢｓＡｇ和抗ＨＥＶ均阳性患者３６例作为重叠组，以单纯ＨＢＶ感染患者３６例作为对照组。两组病例抗ＨＡＶ－ＩｇＭ和抗ＨＣＶ均为阴性。采用ＥＬＩＳＡ法测定两组的ＨＢＶ－Ｍ。结果：重叠组血清ＨＢｅＡｇ的阳性率明显低于对照组（Ｐ＜０．００１），抗ＨＢｅ阳性率明显高于对照组（Ｐ＜０．０５）。结论：ＨＢＶ与ＨＥＶ重叠感染后，ＨＢＶ的复制受到一定程度的抑制
Objective: To observe the influence of hepatitis B virus (HBV) and hepatitis E virus (HEV) overlapping infection on HBV replication. Methods: Thirty-six patients with positive serum HBsAg and anti-HEV were selected as the overlapping group and 36 patients with pure HBV infection as the control group. Both groups were negative for anti-HAV-IgM and anti-HCV. HBV-M was measured by ELISA in both groups. Results: The positive rate of HBeAg in the overlap group was significantly lower than that in the control group (P <0.001), and the positive rate of anti-HBe was significantly higher than that in the control group (P <0.05). Conclusion: The replication of HBV is inhibited to a certain degree after HBV and HEV overlap infection