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目的观察甲基强的松龙联合丙种球蛋白治疗重症手足口病的临床效果。方法选取医院收治的重症手足口病患儿107例,随机分为观察组54例和对照组53例。对照组给予甘露醇、常规降温及应用利巴韦林抗病毒治疗,按1.0g/kg体质量剂量静脉输入丙种球蛋白;观察组在对照组基础上采用甲基强的松龙联合治疗,观察2组患儿临床治疗效果。结果观察组总有效率为87.04%,高于对照组的71.70%,差异有统计学意义(P<0.05)。结论甲基强的松龙联合丙种球蛋白治疗重症手足口病临床效果显著,值得推广应用。
Objective To observe the clinical effect of methylprednisolone combined with gamma globulin in the treatment of severe hand-foot-mouth disease. Methods A total of 107 children with severe HFMD admitted to the hospital were randomly divided into observation group (54 cases) and control group (53 cases). The control group was given mannitol, conventional cooling and ribavirin antiviral therapy, according to 1.0g / kg body weight intravenous gamma globulin; the observation group in the control group based on the combination of methylprednisolone treatment, observed 2 groups of children with clinical treatment. Results The total effective rate in observation group was 87.04%, which was higher than that in control group (71.70%), the difference was statistically significant (P <0.05). Conclusion Methylprednisolone combined with gamma globulin in the treatment of severe hand-foot-mouth disease is clinically effective and should be widely applied.