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新生儿红斑狼疮综合征(NLES)为罕见疾病,常以狼疮性皮损或/和孤立先天性心脏阻滞为特点,其母约40%有SLE或干燥(Sjoren)综合征表现,但在患婴出生时却多无症状。迄今报道,几乎所有母婴皆为抗-La(SS-B)或/和抗-Ro(SS-A)抗体阳性。作者报道2例,均为初孕顺产第一胎男婴,黑、白人各一,母亲产前均有SLE史但产时无症状。例1,8周,面、头皮、颈、臂和躯干现环形红斑5天,面部为主,稍水肿,无脱屑,皮损多呈靶形。例2,3(1/2)周,早产,出生时面部有红色脱屑皮损,伴毛细血管扩张和滤泡栓,硬腭浅表溃疡,活检符合红斑狼疮诊断。两例皮损均不够典型。凝胶双向扩散法检查母、婴血清抗-U_1RNP抗体均为阳性,并经酶联免疫
Neonatal lupus erythematosus syndrome (NLES) is a rare disease characterized by lupus lesions and / or isolated congenital heart disease. About 40% of its mothers have SLE or Sjoren syndrome, Infants are asymptomatic at birth. It has been reported to date that almost all mothers and babies are positive for anti-La (SS-B) or / and anti-Ro (SS-A) antibodies. The authors reported 2 cases, both first-trimester first-birth fetus baby boy, black and white one, the mother had a prenatal history of SLE but asymptomatic during labor. Cases 1, 8 week, face, scalp, neck, arm and torso ring erythema 5 days, the main facial, a little edema, no scaling, skin lesions were mostly target-shaped. Cases 2, 3 (1/2) weeks, premature delivery, born with red scaling skin lesions, with telangiectasia and follicular plug, superficial palatal ulcers, biopsy consistent with the diagnosis of lupus. Two cases of skin lesions are not enough typical. Gel bi-directional diffusion method to check the mother and baby serum anti-U_1RNP antibodies were positive, and by enzyme-linked immunosorbent