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根据临床流行病学调查和实验研究,已明确高密度脂蛋白(HDL)和缺血性心脏病(动脉粥样硬化)的发病率呈负相关。动脉粥样硬化的发生和血清HDL-胆固醇的量降低有密切关系,HDL是一保护因子,可防止动脉粥样斑块形成。HDL是一种脂质和蛋白的复合体,组成它的主要载脂蛋白有apoA_1, A_2,A_4,apoB,apoC和apoE等,其中以apoA_1所占的比例最大,约为65％。体外细胞实验表明,HDL抑制低密度脂蛋白(动脉粥样硬化的主要致病因子)穿过动脉内膜,并抑制内皮细胞和LDL结合
According to clinical epidemiological investigations and experimental studies, it has been clarified that the incidence of HDL and ischemic heart disease (atherosclerosis) is negatively correlated. The occurrence of atherosclerosis and serum HDL-cholesterol is closely related to the reduction of HDL is a protective factor, to prevent the formation of atherosclerotic plaques. HDL is a complex of lipids and proteins. The main apolipoproteins that make up it are apoA_1, A_2, A_4, apoB, apoC and apoE, among which apoA_1 accounts for about 65% of the total. In vitro cell experiments show that HDL inhibits low-density lipoprotein (a major causative agent of atherosclerosis) across the arterial intima and inhibits the binding of endothelial cells to LDL