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最近报道,纯化的伤寒杆菌Vi多糖菌苗在尼泊尔和南非德兰士瓦东部现场试验中有抗伤寒效力。保护作用至少持续1年和1年半,推测这是由菌苗接种诱发的血清Vi抗体介导的。对马里兰大学和图尔斯大学以及智利空军新兵中的志愿者进行的Ⅰ期研究表明,接种Vi多糖菌苗后Vi抗体明显升高。作者对马里兰大学24名接种Vi菌苗的志愿者随访观察了36个月。 24名志愿者接种Vi多糖菌苗50μg,接种前和接种后3周(24名志愿者),21个月(19
Recently, purified S. typhi Vi polysaccharide vaccine has been reported to have an anti-typhoid effect in field trials in eastern Transvaal, Nepal and South Africa. The protective effect lasts at least one year and one and a half years, presumably this is mediated by sera Vi antibody induced by vaccine inoculation. A phase I study of volunteers at the University of Maryland and the University of Tours and the Chilean Air Force recruits showed a marked increase in Vi antibodies after vaccination with Vi polysaccharides. The authors followed 24 volunteers who were vaccinated with Vi vaccine at the University of Maryland for 36 months. Twenty-four volunteers received 50 μg of Vi polysaccharide vaccine, pre-vaccination and 3 weeks post-vaccination (24 volunteers), 21 months (19