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引起急性循环衰竭主要因素是蛇毒对血液、循环系统的影响,可能与下列几个方面有关: (1)血管活性物质释放:卵磷脂酶使肌体细胞释放组织胺及5-羟色胺,蛋白水解酶作用于血浆,α_2-球蛋白释放出缓动素,使毛细血管扩张,通透性增加,引起局部肢体高度肿胀,使大部份血液分布到末梢血管床,导致血容量不足,血压下降。 (2)血容量改变:血循毒还可使毛细血管壁损害,凝血障碍,引起局部及全身反复出血。失血过多时,可导致有效循环血容量骤减,引起血压下降,循环障碍。
Acute circulatory failure caused by the main factor is the snake venom on the blood, circulatory system, may be related to the following aspects: (1) the release of vasoactive substances: lecithin somatic cells release histamine and serotonin, proteolytic enzyme In plasma, α 2 -globin release of tubercle telangiectasia, increased permeability, causing local swelling of the limbs, the majority of blood distribution to the peripheral vascular bed, resulting in hypovolemia, decreased blood pressure. (2) blood volume changes: blood circulation can also make the capillary wall damage, coagulation disorders, causing local and systemic repeated bleeding. Excessive blood loss, can lead to significant loss of circulating blood volume, causing blood pressure, circulatory disorders.