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[Objective] To design the extraction technology of flavonoids from the shells of tarlary buckwheat by SPSS 19.0 software, and to optimize the extraction technology. [Method] Orthogonal test with four factors and three levels was designed by SPSS 19.0 software. Ethanol concentration, extraction times, solid-liquid ratio and extraction time were taken as the investigation factors; and extraction rate of rutin was taken as the index. Extraction technology of flavonoids from tarlary buckwheat shells, which were the byproducts of tarlary buckwheat processing, was optimized. [Result] The optimal technology for reflux extraction of rutin from the shells of tarlary buckwheat were A2B2C1D3, which were 1∶20 solid-liquid ratio, 20 times of 75% ethanol, 3 extraction times, and 1 h extraction time. [Conclusion] SPSS 19.0 software showed the advantages of powerful function and convenient utilization in the aspects of test design and data treatment. It saved time and energy during the data processing to a large extent, which was a kind of statistical software worthy of popularization and application.