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本实验采用国外新近提出的一项能综合评价机体气体交换系统中各氧降阶差时运氧能力的适应水平高低的重要指标──氧比传导(MO2-SC),研究了高原鼠兔气体交换系统运氧能力的低氧适应特征及规律。结果表明,对照条件下,在吸入气(I)至肺泡气(A)(I→A)、A至动脉血(a)(A→a)、a至混合静脉血(v)(a→v)及I→v各阶差中,以A→a的MO2-SC运氧能力最大。低氧15mm后,I→A及a→v的MO2-SC均显著升高,并以I→A增加最为显著,该水平运氧能力是对照的2倍,增长120.9%;而A→a及I→vMO2-SC变化无显著性差异。低氧30min时,I→A的MO2-SC继续显著增长,运氧能力是对照的2.7倍,增长170.7%,其余3个氧降阶差的MO2-SC无显著性改变。以上结果表明,高原鼠兔低氧代偿贮备较大,尤以肺泡气至动脉血阶差最为重要,而通气氧传导能力的增强也是高原鼠兔低氧适应的主要原因。
In this study, a newly proposed oxygen scavenger (MO2-SC), which is an important indicator that can be used to evaluate the oxygenation ability of oxygen evolution in the gas exchange system, Hypoxic Oxygen Adaptation Characteristics and Rules of System Oxygen Capacity. The results showed that under control conditions, there was no significant difference between inhaled gas (I) to alveolar gas (A → A), A to arterial (A → a), a to mixed venous (v → ) And I → v in each step, with A → a MO2-SC oxygen capacity of the largest. After 15mm of hypoxia, MO2-SC of I → A and a → v increased significantly, and I → A increased the most significantly. The level of aerobic capacity was double that of control, increasing by 120.9%; while A → a and I → vMO2-SC changes no significant difference. At 30 min of hypoxia, the MO2-SC of I → A continued to increase significantly. The aerobic capacity was increased by 170.7% and the aerobic capacity was increased by 170.7%. The MO2-SC of the other three oxygen reduction steps had no significant change. The above results show that plateau pikas have a large hypoxia reserve, especially the difference of alveolar gas to arterial blood level is the most important, and the enhancement of ventilation oxygen permeability is also the main reason of hypoxia adaptation in plateau pikas.