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胃肠间质瘤(GIST)是胃肠道最常见的间质肿瘤。长期以来外科治疗是首选也是惟一的治疗手段,随着GIST靶向治疗的到来,外科治疗模式也不断发展。无论是手术原则、手术技术、手术时机,还是手术联合靶向治疗为主的多学科治疗模式,都在循证医学的基础上进行了细化和发展。外科完全切除仍是原发局限可切除GIST治疗的金标准。而对于进展期GIST,靶向治疗的介入彻底改变了此类病人的预后。对伊马替尼治疗有效的进展期GIST病人,联合外科手术切除为主的综合治疗模式是目前研究的热点。
Gastrointestinal stromal tumor (GIST) is the most common gastrointestinal stromal tumor. For a long time, surgical treatment is the first and only treatment. With the advent of GIST targeted therapy, the surgical treatment model is also developing. Both the principle of surgery, surgical techniques, timing of surgery, or surgery combined with targeted therapy-based multidisciplinary treatment model are based on evidence-based medicine were refined and developed. Surgical total resection is still the gold standard for the treatment of patients with locally advanced resectable GIST. For advanced GIST, the intervention of targeted therapy has completely changed the prognosis of such patients. Imatinib-effective treatment of advanced GIST patients, combined with surgical resection-based comprehensive treatment model is currently the focus of research.