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目的探讨连续性血液滤过(CVVH)对急性呼吸窘迫综合征(ARDS)患者血中肿瘤坏死因子(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)的影响。方法选择ARDS患者16例,行CVVH治疗,治疗前和治疗后不同时间取血和超滤液检测炎症介质的浓度。结果 CVVH治疗后6~9 h炎症介质水平达最低,与治疗前相比差异有统计学意义(P<0.05)。结论 CVVH对炎症介质清除有效,治疗6~9 h达最低水平。
Objective To investigate the effects of continuous hemofiltration (CVVH) on the levels of tumor necrosis factor (TNF-α), interleukin-1β (IL-1β) and interleukin-8 (IL-1β) in patients with acute respiratory distress syndrome (ARDS) 8) the impact. Methods Sixteen ARDS patients were selected for CVVH treatment. Before and after treatment, blood and ultrafiltrate were used to detect the concentration of inflammatory mediators. Results The level of inflammatory mediators was the lowest at 6 ~ 9 h after CVVH treatment, and the difference was statistically significant compared with that before treatment (P <0.05). Conclusions CVVH is effective in removing inflammatory mediators and reaches the lowest level after 6 ~ 9 h of treatment.