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目的研究前列腺增生(BPH)的各种危险因素及其危害程度。方法以132例病理确诊的前列腺增生患者为病例组,以年龄匹配的132例无前列腺增生患者为对照组进行1∶1配对病例对照研究。采集人口学因素、高血压史、糖尿病史、实验检测等临床资料。资料分析采用单因素和多因素条件Logistic回归分析。结果 (1)单因素分析显示:在吸烟、饮酒、糖尿病史、高血压史、慢性支气管炎史、肾囊肿史和慢性前列腺炎史差异统计学意义(P<0.05)。(2)多因素分析显示:吸烟(OR=0.530)、糖尿病史(OR=2.227)、高血压史(OR=1.862)、慢性前列腺炎(OR=2.414)是BPH的独立危险因素(P<0.05)。结论前列腺炎史、高血压史`、糖尿病史是BPH发病的危险因素,吸烟为保护性因素。良好的血压和血糖控制是预防BPH的重要方法。
Objective To study the various risk factors of benign prostatic hyperplasia (BPH) and their harmfulness. Methods A total of 132 pathologically confirmed cases of benign prostatic hyperplasia (BPH) were selected as the case group and 132 age-matched BPH patients as the control group. Collected demographic factors, history of hypertension, history of diabetes, laboratory tests and other clinical data. Data analysis using univariate and multivariate conditional logistic regression analysis. Results (1) Univariate analysis showed that there was significant difference in the history of smoking, drinking, history of diabetes, history of hypertension, history of chronic bronchitis, history of renal cysts and chronic prostatitis (P <0.05). (2) Multivariate analysis showed that smoking (OR = 0.530), history of diabetes (OR = 2.227), history of hypertension (OR = 1.862) and chronic prostatitis (OR = 2.414) were independent risk factors for BPH ). Conclusions History of prostatitis, history of hypertension, history of diabetes mellitus is a risk factor for BPH and smoking is a protective factor. Good blood pressure and glycemic control are important ways to prevent BPH.