论文部分内容阅读
目的 探讨GSTM1基因多态性与膀胱癌遗传易感性的关系。 方法 采用PCR技术 ,以病例 对照研究方法 ,对 6 9例膀胱癌患者和 88例健康对照者的GSTM 1基因型进行检测。 结果 膀胱癌患者GSTM1空白基因型频率为 5 8% ,对照组为 4 1% ,两组比较差别有显著性意义 (χ2 =4 .5 1,P <0 .0 5 ) ,OR值为 2 .0 (95 %CI =1.0 5～ 3.79)。吸烟者中 ,患者组GSTM1空白基因型频率为71% ,对照组为 2 4 % ,两组比较差别有显著性意义 (χ2 =2 2 .6 ,P <0 .0 1) ,OR值为 8.3(95 %CI =3.34～ 2 0 .6 5 )。以GSTM1非空白型 /不吸烟者为参照 ,GSTM1空白型 /吸烟者的OR值为 4 .6 4 (95 %CI=1.86～ 11.37,χ2 =11.6 3,P <0 .0 1) ,差别有显著性意义。 结论 GSTM 1基因多态性与膀胱癌易感性有关 ,在膀胱癌的发生发展中与吸烟协同起作用
Objective To investigate the relationship between GSTM1 gene polymorphism and genetic susceptibility to bladder cancer. Methods GSTM 1 genotypes of 69 bladder cancer patients and 88 healthy controls were detected by PCR and case-control study. Results The frequency of GSTM1 genotype was 58% in bladder cancer patients and 41% in control subjects. There was significant difference between the two groups (χ2 = 4.51, P <0.05). 0 (95% CI = 1.05 ~ 3.79). Among smokers, the frequency of GSTM1 genotype was 71% in patients and 24% in controls. There was significant difference between the two groups (χ2 = 2.2 2, P <0.01), OR was 8.3 (95% CI = 3.34 ~ 20.65). According to GSTM1 non-blank / non-smokers, the OR of GSTM1 blank / smoker was 4.64 (95% CI = 1.86-11.37, χ2 = 11.63, P <0.01) Significant significance. Conclusion GSTM 1 gene polymorphism is associated with bladder cancer susceptibility and synergistic effect with smoking in the development of bladder cancer