论文部分内容阅读
目的:观察儿童哮喘不同病期血清可溶性白细胞介素-2受体(sIL-2R)水平。方法:采用双抗体夹心 ELISA 法对26例儿童哮喘急性发作(发作组)、16例哮喘急性发作中给予糖皮质激素治疗(发作+激素治疗组)、20例儿童哮喘临床控制(缓解组)和20名健康儿童的血清 sIL-2R 水平进行测定。结果:发作组血清 sIL-2R 水平(539.76±143.82U/ml)显著高于缓解组(297.21±72.16U/ml,P<0.01)和对照组(246.18±63.24U/ml,P<0.01),发作+激素治疗组血清 sIL-2R 水平(386.42±97.40/ml)较治疗前显著降低(P<0.05),但仍明显高于缓解组(P<0.05),缓解组血清 sIL-2R 与对照组比仍在较高水平(P<0.05);发作组血清 sIL-2R 水平与 PaO_2呈显著负相关(r=-0.7215,P<0.01),发作+激素治疗组中各例血清 sIL-2R 水平较治疗前的变化值与 PaO_2变化值亦呈显著负相关(r=-0.4316,P<0.05)。结论:sIL-2R 可能涉及儿童哮喘发作的病理生理过程。
Objective: To observe the serum soluble interleukin-2 receptor (sIL-2R) levels in children with asthma at different stages. Methods: Twenty-six children with acute asthma attack (seizure group), 16 patients with acute asthma attack were treated with glucocorticoid (seizure plus hormone therapy), 20 children with asthma (control group) and Serum sIL-2R levels were measured in 20 healthy children. Results: The level of sIL-2R in the seizure group was significantly higher than that in the remission group (297.21 ± 72.16U / ml, P <0.01) and the control group (246.18 ± 63.24U / ml, P <0.01) Serum levels of sIL-2R in the seizure + hormone group were significantly lower than those in the remission group (386.42 ± 97.40 / ml) (P <0.05), but still significantly higher than those in the remission group (P <0.05) (P <0.05). Serum sIL-2R level was significantly negatively correlated with PaO 2 in the seizure group (r = -0.7215, P <0.01). Serum levels of sIL-2R in each seizure plus hormone group were significantly higher than those in the seizure group The changes before treatment and PaO 2 also showed a significant negative correlation (r = -0.4316, P <0.05). Conclusion: sIL-2R may be involved in the pathophysiological process of childhood asthma attacks.