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目的观察哮喘-慢性阻塞性肺疾病重叠综合征(asthma-chronic obstruct pulmonary disease overlap syndrome,ACOS)患者骨质疏松(osteoporosis,OP)的骨密度(bone mineral density,BMD)。方法选取2014年10月—2015年7月间本院52例住院ACOS患者作为ACOS组,选取同期住院的48例慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者作为COPD组,选取54肺功能正常的健康同龄人作为对照组,分别测量其BMD值,计量资料比较采用进行方差分析,两两比较采用LSD法,P<0.05为差异有统计学意义。结果 ACOS组、COPD组及对照组的L2~L4、股骨颈的BMD值[(1.108±0.131)、(1.139±0.099)、(1.118±0.138)、(0.960±0.064)g/cm2,(0.951±0.143)、(0.986±0.152)、(0.979±0.143)、(0.849±0.114)g/cm2与(0.902±0.043)、(0.941±0.037)、(0.923±0.053)、(0.811±0.049)g/cm2]比较,差异均有统计学意义(均P<0.05)。两两比较发现,ACOS组和COPD组的L2~L4、股骨颈的BMD值均较对照组低,差异均有统计学意义(均P<0.05);ACOS组的L2~L4、股骨颈的BMD值较COPD组低,差异均有统计学意义(均P<0.05)。结论 ACOS患者的BMD值较单纯COPD患者和健康同龄人均低,ACOS患者应尽早进行BMD测定,以对OP做到早期诊断及治疗。
Objective To observe the bone mineral density (BMD) of osteoporosis (OP) in patients with asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS). Methods From October 2014 to July 2015, 52 hospitalized patients with ACOS in our hospital were selected as the ACOS group. Forty-eight patients with chronic obstructive pulmonary disease (COPD) were enrolled as COPD group and 54 lung Normal healthy peers as the control group, respectively, to measure the BMD value, measurement data were compared using analysis of variance, two by two comparison using LSD method, P <0.05 for the difference was statistically significant. Results The BMD of L2 ~ L4 and femoral neck in ACOS group, COPD group and control group [(1.108 ± 0.131), (1.139 ± 0.099), (1.118 ± 0.138), (0.960 ± 0.064) g / cm2, 0.983 ± 0.143, 0.986 ± 0.152, 0.979 ± 0.143, 0.849 ± 0.114 g / cm2 and 0.902 ± 0.043, 0.941 ± 0.037, 0.923 ± 0.053, 0.811 ± 0.049 g / cm2 ], The differences were statistically significant (all P <0.05). The comparisons between two groups showed that the BMD of L2 ~ L4 and femoral neck in ACOS group and COPD group were lower than those in control group (all P <0.05), while those in L2 ~ L4 in ACOS group and BMD in femoral neck Lower than the COPD group, the differences were statistically significant (P <0.05). Conclusion The BMD of patients with ACOS is lower than that of patients with COPD and healthy peers. Patients with ACOS should have BMD as soon as possible in order to make early diagnosis and treatment of OP.