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雌激素通过分布于细胞膜的雌激素结合蛋白,激活细胞内信号级联放大反应,从而改变胞内蛋白功能和调控基因表达,此为雌激素非基因组作用模式或称膜启动的雌激素应答。雌激素基因组与非基因组作用的交叉对话在调控转录中有重要意义。在人类乳腺癌的发生、发展和转化过程中,除由雌激素诱导的核内事件外,膜启动的雌激素应答同样影响细胞的增殖与凋亡机制。
Estrogen activates intracellular signaling cascades through estrogen-binding proteins distributed in the cell membrane, thereby altering intracellular protein function and regulating gene expression, a non-genomic estrogen-mode or membrane-initiated estrogen response. Cross-talk between estrogen and non-genomic functions is important in regulating transcription. In addition to the intranuclear events induced by estrogen in the development, progression and transformation of human breast cancer, the membrane-initiated estrogen response also affects the cell proliferation and apoptosis mechanisms.