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目的:探讨胃癌血瘀证患者p53、VEGF在胃癌组织中表达的关系,为胃癌的中医分型提供一定的理论依据。方法:选择2011年3月—2013年3月我院收治的经手术治疗的胃癌患者80例,按照中医分型将其分为血瘀证组以及非血瘀证组,每组40例,采用免疫组化方法比较两组患者胃癌组织中p53以及VEGF的表达情况。结果:血瘀证组患者胃癌组织p53阳性表达率为77.50%,非血瘀证组患者胃癌组织p53阳性表达率为42.50%,两组比较差异具有统计学意义(P<0.05);血瘀证组患者胃癌组织VEGF阳性表达率为92.50%,非血瘀证组患者胃癌组织VEGF阳性表达率为57.50%,两组比较差异具有统计学意义(P<0.05)。结论:p53以及VEGF可能为胃癌血瘀证患者的物质基础之一,同时p53与VEGF在胃癌组织中的表达可以作为胃癌血瘀证患者的一种辅助诊断指标。
Objective: To investigate the relationship between the expression of p53 and VEGF in gastric cancer with gastric cancer with blood stasis syndrome, and to provide a theoretical basis for the TCM classification of gastric cancer. Methods: Eighty patients with gastric cancer treated in our hospital from March 2011 to March 2013 were divided into two groups according to TCM classification: blood stasis syndrome group and non-blood stasis syndrome group, 40 cases in each group Immunohistochemistry was used to compare the expression of p53 and VEGF in gastric cancer tissue between the two groups. Results: The positive expression rate of p53 in gastric cancer tissue was 77.50% in blood stasis syndrome group and 42.50% in gastric cancer tissue in non-blood stasis syndrome group, the difference was statistically significant (P <0.05) The positive expression rate of VEGF in gastric cancer tissues was 92.50%, while the positive expression rate of VEGF in non-blood stasis syndrome patients was 57.50%. The difference between the two groups was statistically significant (P <0.05). Conclusion: p53 and VEGF may be one of the material bases for patients with gastric cancer with blood stasis syndrome. Meanwhile, the expression of p53 and VEGF in gastric cancer may be used as a diagnostic index for patients with gastric cancer with blood stasis syndrome.