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目的 研究扩张性心肌病 (扩心病 )患者内皮依赖性 (简称血管内皮功能 )和内皮非依赖性血管舒张功能是否受损。方法 采用高分辨血管外超声法测定 40例扩心病患者和 42例无扩心病对照组肱动脉血流介导的血管内皮功能和舌下含服硝酸甘油( 0 5mg)后内皮非依赖性血管舒张功能。结果 扩心病患者血流介导性的肱动脉舒张 [( 2 3 2± 2 10 ) % ]较对照组 [( 7 87± 4 15 ) % ]明显降低 (P <0 0 1) ,含服硝酸甘油后的肱动脉舒张 [( 16 89± 11 5 7) % ]也较对照组 [( 2 2 83± 6 93 ) % ]明显受损 (P <0 0 5 )。结论 扩心病患者外周血管内皮功能和内皮非依赖性血管舒张功能均受损
Objective To investigate whether endothelium-dependent (vascular endothelial function) and endothelium-independent vasodilation are impaired in patients with dilated cardiomyopathy (dilated cardiomyopathy). Methods The endothelium-independent vasodilatation after brachial artery blood flow-mediated endothelial function and sublingual nitroglycerin (0 5 mg) were determined in 40 patients with dilated cardioplegia and 42 patients without dilated cardiomyopathy by high resolution extracorporeal ultrasonography. Features. Results Compared with the control group [(87 87 ± 4 15)%], the flow-mediated brachial artery diastole in patients with heart disease was significantly lower (P <0.01) Brachial artery relaxation after glycerol [(16 89 ± 11 57)%] was also significantly impaired (22 83 ± 6 93%) in the control group (P 0 05). Conclusion The peripheral vascular endothelium function and endothelium-independent vasodilatation in patients with heart disease are impaired