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目的:观察脾氨肽口服冻干粉预防手足口病的疗效及安全性。方法:将未患过手足口病且平时身体健康的在我院保健门诊就诊1~2岁儿童按自愿原则分成观察组198例和对照组285例。观察组给予脾氨肽口服冻干粉,每日1支,共4周;对照组未给予任何预防措施。同时按自愿原则分别于入选时、3个月时及发病时检测小儿血清IgG、IgA和IgM。比较两组手足口病的发生情况及不同时期血清免疫球蛋白的变化。结果:观察组有19例发病,发生率9.6%,对照组50例发病,发生率17.5%,两组比较差异有统计学意义(P<0.01);观察组血清IgG、IgA和IgM在3个月时均显著高于对照组;发病时两组手足口病患儿的IgG、IgA均显著低于发病前的水平,但IgM水平明显高于发病前水平;观察组发病时患儿的血清IgG、IgA和IgM水平高于对照组,差异有统计学意义;观察组发病高峰在7月份,而对照组发病高峰在5月份。结论:脾氨肽可能通过提高小儿的体液免疫功能,在预防手足口病方面有一定作用。
Objective: To observe the efficacy and safety of splenomegaly oral freeze-dried powder in preventing hand-foot-mouth disease. Methods: The children who did not have hand, foot and mouth disease and were generally healthy were divided into observation group (198 cases) and control group (285 cases) according to the voluntary principle in the health clinic of our hospital. The observation group was given splenic amlodipine oral lyophilized powder, a day for a total of 4 weeks; the control group did not give any preventive measures. At the same time, according to the principle of voluntariness, serum IgG, IgA and IgM in children were detected at the time of enrollment, 3 months and at the time of onset respectively. The occurrence of HFMD in both groups and the changes of serum immunoglobulin in different periods were compared. Results: There were 19 cases in the observation group, the incidence rate was 9.6%, and 50 cases in the control group, the incidence rate was 17.5% (P <0.01). Serum IgG, IgA and IgM in the observation group were significantly higher in 3 Month were significantly higher than the control group; onset of HFMD children IgG, IgA were significantly lower than before the onset of the level, but IgM levels were significantly higher than the pre-morbidity levels; the incidence of disease in the observation group of children with serum IgG , IgA and IgM levels higher than the control group, the difference was statistically significant; the peak incidence in the observation group in July, while the peak incidence in the control group in May. Conclusion: Spleen ammonia peptide may play a role in preventing hand-foot-mouth disease by improving humoral immune function in children.