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米非司酮以其和孕酮受体极强的亲和力竞争蜕膜细胞上的受体、阻断孕酮的怍用,使蜕膜变性,绒毛膜促性腺激索(hCG)下降,卵巢黄体溶解,胚胎停止发育;蜕膜坏死释放前列腺素,使子宫收缩,宫颈软化,增加了子宫对外源性前列腺素的敏感性,从而达到抗早孕作用。1993年8月—1994年8月,采用米非司酮配伍米索前列醇口服终止早孕1000例,现总结如下: 对象和方法 1.对象:早孕健康妇女1000例,年龄21～24岁,停经38～70天,既往有足月分娩和人流史540例,初孕妇女460例。
Mifepristone competes with receptors on the decidual cells for its strong affinity to the progesterone receptor, blocking the use of progesterone, degeneration of the decidua, reduction of hCG, Dissolution, the embryo stop development; decidual necrosis release of prostaglandins, uterine contraction, cervical softening, increased uterine sensitivity to exogenous prostaglandins, so as to achieve anti-early pregnancy effect. August 1993 - August 1994, the use of mifepristone and misoprostol orally terminated 1000 cases of early pregnancy, are summarized as follows: Subjects and methods 1. Subjects: 1000 healthy pregnant women, aged 21 to 24 years old, menopause 38 to 70 days, with a history of full-term labor and history of 540 cases of early pregnant women, 460 cases.