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目的探讨JWAT723G多态性与胃癌易感性之间的关系。方法采用多聚酶链反应(polymerase chain reaction,PCR)和变性高效液相色谱法(denaturing high performance liquid chromatography,DHPLC)检测107例胃癌患者和200例同龄健康人群的JWAT723G多态性并进行分析。结果病例组和对照组JWAT723G基因分布频度无显著差异(χ2=2.290,P=0.318)。在调整了性别和年龄后,与T/T基因型相比,T/G基因型发生胃癌的危险性上升到1.21(95%CI:0.94～1.57),G/G基因型发生胃癌的危险性上升到1.49(95%CI:0.45～4.96)。合并T/G和G/G基因型分析显示G等位基因发生胃癌的危险性上升到1.21(95%CI:0.95～1.55),JWAT723G多态性与胃癌的易感性无相关性(P=0.1316)。结论 JWAT723G多态性与胃癌易感性不相关。
Objective To investigate the relationship between JWAT723G polymorphism and gastric cancer susceptibility. Methods Polymorphisms of JWAT723G in 107 gastric cancer patients and 200 healthy people of same age were detected by polymerase chain reaction (PCR) and denaturing high performance liquid chromatography (DHPLC). Results There was no significant difference in the frequency of JWAT723G gene between cases and controls (χ2 = 2.290, P = 0.318). After adjusting for gender and age, the risk of gastric cancer in the T / G genotype increased to 1.21 (95% CI: 0.94 to 1.57) compared with the T / T genotype, and the risk of gastric cancer in the G / G genotype Rose to 1.49 (95% CI: 0.45 to 4.96). Analysis of the combined T / G and G / G genotypes showed that the risk of gastric cancer with the G allele increased to 1.21 (95% CI: 0.95-1.55), and there was no association between JWAT723G polymorphism and gastric cancer susceptibility (P = 0.1316 ). Conclusion JWAT723G polymorphism is not associated with gastric cancer susceptibility.