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目的:探讨新疆地区维吾尔族、汉族癫痫患儿拉莫三嗪血药浓度是否存在差异。方法:采用高效液相色谱法(HPLC)对60例服用拉莫三嗪的癫痫患儿进行拉莫三嗪血清稳态药物浓度测定,分析其血药浓度与族别的关系。结果:在推荐剂量1~5mg/(kg·d)范围内,相同条件下,不同族别组患儿拉莫三嗪血清药物浓度比较差异无统计学意义(P>0.05)。结论:在推荐剂量范围内,新疆地区维吾尔族、汉族癫痫患儿拉莫三嗪血清药物浓度与族别无相关性。
Objective: To investigate whether there is a difference in plasma concentration of lamotrigine between Uygur and Han children with epilepsy in Xinjiang region. Methods: Sixty children with epilepsy who took lamotrigine were determined by HPLC. The steady-state drug concentration of lamotrigine was determined, and the relationship between the plasma concentration and the race was analyzed. Results: There was no significant difference in the serum concentration of lamotrigine among children of different ethnic groups at the recommended dose of 1 ~ 5 mg / (kg · d) under the same conditions (P> 0.05). Conclusion: There is no correlation between the concentration of lamotrigine and the ethnic group of Uygur and Han children with epilepsy in Xinjiang in the recommended dose range.