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目的 :研究心血管病患者血浆N 端脑钠素前体 (NT ProBNP)浓度与心力衰竭严重程度的关系。方法 :电化学发光双抗体夹心免疫法测定 65例心血管病患者及 16名健康体检者血浆NT ProBNP浓度 ,超声心动图测定不同心功能组患者心脏结构和功能 ,分析血浆NT ProBNP浓度、超声指标与NYHA心功能分级的关系。结果 :方差分析显示心血管病患者血浆NT ProBNP浓度显著高于健康体检者 ,且随着心力衰竭程度的加重而显著增加 (P <0 0 0 1)。多因素偏相关分析表明血浆NT ProBNP浓度和左心室舒张末期容积与NYHA心功能分级之间具有良好的正相关 (r =0 769,P <0 0 0 1及r =0 3 76,P =0 0 2 0 )。血浆NT ProBNP浓度 >2 0 0 pg/ml诊断心力衰竭的敏感性 10 0 % ,特异性 97% ,阳性预测值 98% ,阴性预测值 10 0 %。结论 :心血管病患者血浆NT ProBNP浓度随着心力衰竭严重程度的增加而升高 ,是评价心功能的敏感指标。
AIM: To investigate the relationship between plasma N-terminal proBNP levels and the severity of heart failure in patients with cardiovascular diseases. Methods: The plasma concentrations of NT ProBNP in 65 patients with cardiovascular disease and 16 healthy subjects were measured by sandwich enzyme-linked immunosorbent assay (ELISA). The cardiac structure and function of patients with different cardiac function were measured by echocardiography. The plasma concentrations of NT ProBNP, Relationship with NYHA Cardiac Function Classification. Results: ANOVA showed that plasma NT ProBNP levels in patients with cardiovascular disease were significantly higher than those in healthy subjects and significantly increased with the severity of heart failure (P <0.01). Multivariate partial correlation analysis showed a positive correlation between plasma NT ProBNP concentration and left ventricular end-diastolic volume and NYHA functional class (r = 0 769, P <0 0 01 and r 0 3 76, P 0 0 2 0). Plasma NT ProBNP concentration> 200 pg / ml was 100% sensitive, 97% specific, positive predictive value 98%, and negative predictive value 100%. Conclusion: The plasma NT ProBNP level in patients with cardiovascular disease increases with the severity of heart failure, which is a sensitive index to evaluate cardiac function.