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利用ＲＩＡ法测定经皮层ＥＥＧ、ＰＥＴ、ＳＰＥＣＴ、ＭＲＩ、ＣＴ等检查而定位明确的６４例癫痫患者癫痫发作前后血清皮质醇水平。结果表明，癫痫病人血清基础皮质醇水平明显低于正常人。癫痫发作后９２．２％的病人血清中皮质醇水平升高，４０．６％的病人发作后１５分钟皮质醇水平达到峰值，失神性发作后血清皮质醇水平不增加或增加不明显，而强直－阵挛性、复杂部分性发作后皮质醇水平明显升高。然而发作后血清皮质醇水平的变化与癫痫灶位置无关，不同病灶的癫痫患者癫痫发作后均可引起皮质醇水平升高。结果提示癫痫过程影响下丘脑－垂体－肾上腺（ＨＰＡ）轴的功能活动，使基础皮质醇水平减低，癫痫发作后均可引起不同病灶位置的血清皮质醇水平升高，而且发作类型影响发作后皮质醇水平的变化。
The levels of serum cortisol in epileptic patients before and after epileptic seizure were determined by RIA in 64 cases of epilepsy with well-defined examination by EEG, PET, SPECT, MRI and CT. The results show that serum basal cortisol levels in patients with epilepsy were significantly lower than normal. Serum Cortisol levels increased in 92.2% of patients after seizures, cortisol levels peaked at 15 minutes after onset in 40.6% of patients, serum cortisol levels did not increase or did not increase significantly after denervation episodes, - Clonic, complicated partial seizures significantly increased cortisol levels. However, the change of serum cortisol level after seizure had nothing to do with the location of epileptic foci, epilepsy patients with different lesion could cause cortisol increase after epileptic seizures. The results suggest that epilepsy affects the functional activity of the hypothalamic-pituitary-adrenal (HPA) axis and decreases basal cortisol levels. After epileptic seizures, serum cortisol levels at different focal sites may be elevated, and the type of seizure affects post-seizure cortical Changes in alcohol levels.