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目的探讨氨氯地平联合替米沙坦治疗老年清晨高血压的疗效及逆转左心室肥厚(LVH)的作用。方法选取102例江门市五邑中医院恩平分院2014年7月至2016年7月收治的老年清晨高血压伴LVH患者,给予氨氯地平联合替米沙坦治疗12个月,分别于治疗前及治疗后进行血压测量及超声心动图检查,观察患者治疗效果、血压[收缩压(SBP)、舒张压(DBP)变化]、LVH等相关指标,并注意观察患者治疗期间不良反应发生情况。结果本组102例患者治疗总有效率为96.1%,不良反应发生率仅有3.9%;治疗后患者无论是动态血压还是清晨血压较治疗前均有大幅度降低,LVH相关指标较治疗前也均有所好转,差异均有统计学意义(均P<0.05)。结论采用氨氯地平与替米沙坦联合治疗老年清晨高血压合并LVH患者,可明显控制其血压水平,进而降低心脑血管等并发症发生率,同时对LVH也具有一定的逆转作用。
Objective To investigate the efficacy of amlodipine combined with telmisartan in the treatment of senile early-morning hypertension and the effect of reversing left ventricular hypertrophy (LVH). Methods A total of 102 elderly patients with LVH and elderly patients with LVH admitted to Enping Branch of Wuyi Hospital of Traditional Chinese Medicine from July 2014 to July 2016 were enrolled in the study. Amlodipine and telmisartan were given for 12 months. Before treatment After treatment, blood pressure measurement and echocardiography were performed to observe the therapeutic effect, blood pressure (SBP, DBP), LVH and other related indicators, and observe the adverse reactions during treatment. Results The total effective rate was 96.1% in 102 patients and the incidence of adverse reactions was only 3.9%. After treatment, both ambulatory blood pressure and early morning blood pressure were significantly lower than those before treatment, LVH-related indicators were also significantly lower than before treatment Have improved, the differences were statistically significant (both P <0.05). Conclusions The combination of amlodipine and telmisartan in the treatment of elderly patients with early morning hypertension complicated with LVH can obviously control the blood pressure level and further reduce the incidence of complications such as cardiovascular and cerebrovascular diseases, and also has a certain reversal effect on LVH.