Neuroprotective profiles of anti-aging gene Klotho in Alzheimer disease mouse model

• 作 者: DU Jun-rong ZHAO Yue ZENG Chen
• 机 构: DepartmentofPharmacology
• 出 处: 中国药理学与毒理学杂志
• 发表日期: 2019年6期
• 关键词: KLOTHO ALZHEIMER disease APP/PS1 TRANSGENIC mouse

OBJECTIVE Alzheimer disease(AD) is the most common type of senile dementia. The anti-aging gene Klotho is reported to decline in the brain of patients and animals with AD. However, the role of Klotho in the progression of AD remains elusive. The present s