论文部分内容阅读
血小板活化和内皮细胞损伤存在于临床许多疾病.肝病患者凝血功能障碍,作为凝血活动中心环节的血管内皮及血小板可能起关键作用.血小板α-颗粒膜蛋白(GMP-140)是目前具有特异性的血小板活化的分子标记物,内皮素-1(ET-1)可作为反映肝脏血管内皮细胞损伤的指标,通过对肝硬变患者血浆 GMP-140,ET-1的检测,探讨其在肝硬变病理生理及临床中的意义.1 材料和方法1.1 材料肝炎后肝硬变患者58例,男48例,女10例,年龄24岁～68岁,平均46岁.经病史、体检、肝功能、影象学及内镜检查确诊.并按 Child 肝功能分级 A 级18例,B 级26例,C 级14例;正常对照组30例,男20例,女10例,年龄20岁～52岁,平均
Platelet activation and endothelial cell damage exist in many clinical diseases.Hepatopathy in patients with coagulation disorders, coagulation activity as a central part of the vascular endothelial cells and platelets may play a key role.Platelet-granule membrane protein (GMP-140) is currently specific Endothelin-1 (ET-1), a marker of platelet activation, can be used as an index to reflect the damage of hepatic vascular endothelial cells. The detection of plasma GMP-140 and ET-1 in patients with cirrhosis and its relationship with cirrhosis Pathophysiology and clinical significance.1 Materials and Methods 1.1 Materials58 cases of posthepatitic cirrhosis, 48 males and 10 females, aged 24 years to 68 years, mean 46. The history, physical examination, liver function, Imaging and endoscopy were diagnosed.According to Child’s liver function grading A class 18 cases, B class 26 cases, C class 14 cases; normal control group 30 cases, 20 males and 10 females, aged 20 years old to 52 years ,average