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目的探讨卵巢交界性囊腺瘤术中腹水或冲洗液细胞学检出率与细胞学涂片的形态学特征。方法收集521例术中积液或冲洗液细胞学涂片,回顾性分析了30例卵巢交界性囊腺瘤细胞学涂片,探讨其细胞形态特征及诊断价值。结果 521例积液或冲洗液中,30例为卵巢交界性囊腺瘤,细胞学检出16例(53.3%)。30例中18例为浆液性,10例为黏液性,2例为混合性。卵巢交界性囊腺瘤细胞学涂片显示,细胞异型性不明显,有明显上皮结构可提示为肿瘤而非间皮细胞。增生间皮细胞偶可呈乳头结构,但乳头较平铺,无三维立体感。结论卵巢浆液性交界性囊腺瘤的细胞学检出率相对较高。术中腹水或冲洗液细胞学涂片中,卵巢交界性囊腺瘤细胞/卵巢腺癌细胞与增生活跃的间皮细胞容易鉴别,而交界性囊腺瘤细胞与腺癌细胞较难鉴别。染色质明显增粗和核形不规则是鉴别两者最有意义的形态学特征。
Objective To investigate the cytological detection rate of ascites or fluid in borderline cystadenoma of ovary and morphological features of cytology smears. Methods 521 cases of intraoperative effusion or washing cytology smears were collected, and 30 cases of ovarian borderline cystadenoma cytology smears were retrospectively analyzed to investigate their cell morphological characteristics and diagnostic value. Results In 521 cases of effusion or irrigation fluid, 30 cases were borderline cystadenocarcinoma of the ovary and 16 cases (53.3%) were detected by cytology. 18 of 30 cases were serous, 10 were mucinous and 2 were mixed. Ovarian borderline cystadenoma cytology smear showed cell atypia is not obvious that there is obvious epithelial structure can be prompted to tumor rather than mesothelial cells. Mesothelioma even proliferative papillae structure, but more tiled than nipple, no three-dimensional sense. Conclusion The cytology detection rate of ovarian serous borderline cystadenoma is relatively high. Intraoperative ascites or rinse cytology smears, ovarian borderline cystadenoma / ovarian adenocarcinoma cells and proliferative active mesothelial cells easily identified, and borderline cystadenoma and adenocarcinoma cells more difficult to identify. Significant thickening of the chromatin and nuclear irregularities are the most significant morphological characteristics of both.