论文部分内容阅读
目的探讨云南大理白族血尿酸的分布特点与代谢综合征(MS)及其危险因素的相关性。方法对5 444例包括城市、农村、城乡结合部居住5年以上的大理白族人群进行问卷调查、体格检查和生化指标进行分析。结果1随着血尿酸水平升高,研究对象收缩压、舒张压、甘油三酯、低密度脂蛋白胆固醇、体质量指数、腰臀比逐渐上升,高密度脂蛋白胆固醇逐渐下降(P<0.01);随着血尿酸的升高,空腹血糖、糖化血红蛋白男性差异无统计学意义(P>0.05),女性呈逐渐升高趋势(P<0.01);2高尿酸血症(HUA)及MS患病率男性高于女性;随着年龄增加,患病率逐渐升高(P<0.01);农民、城镇居民、城乡结合部居民患病率逐渐升高(P<0.01)。吸烟史、饮酒史、代谢病家族史男性高于女性(P<0.01);农民、城镇居民、城乡结合部居民所占比例逐渐升高(P<0.01);随着年龄的增加,吸烟史所占比例逐渐下降,饮酒史呈中年增高趋势而代谢疾病家族史呈中年下降趋势(P<0.01)。3随着血尿酸升高,男女性MS患病率逐渐升高(P<0.01)。4MS患病与UA水平有关。在同一年龄组,随着UA水平的增加,MS患病风险呈增加趋势,特别是中、老年女性。结论云南大理白族HUA患病率高,血尿酸水平与MS有关,血尿酸升高是MS的独立危险因素。
Objective To investigate the relationship between the distribution of serum uric acid and the metabolic syndrome (MS) and its risk factors in Bai nationality of Yunnan province. Methods A questionnaire survey, physical examination and biochemical indexes were conducted on 5 444 Dali Bai people living in urban, rural and urban-rural areas for more than five years. Results 1 With the increase of serum uric acid level, systolic blood pressure, diastolic blood pressure, triglyceride, low density lipoprotein cholesterol, body mass index, waist-hip ratio gradually increased and HDL cholesterol decreased gradually (P <0.01) (P <0.01); 2 hyperuricemia (HUA) and MS prevalence (P> 0.05), while there was no significant difference between fasting blood glucose and glycosylated hemoglobin The prevalence was higher in males than in females. The prevalence increased with age (P <0.01). The prevalence of peasants, urban residents and urban-rural areas increased gradually (P <0.01). The smoking history, drinking history and family history of metabolic diseases were higher than those of women (P <0.01). The proportions of peasants, urban residents and inhabitants in urban and rural areas gradually increased (P <0.01). With age, smoking history The proportions decreased gradually. The history of drinking history showed a middle-aged increasing trend while the family history of metabolic diseases showed a decreasing trend in middle age (P <0.01). 3 With the increase of serum uric acid, the prevalence of MS in men and women gradually increased (P <0.01). 4MS prevalence and UA levels. In the same age group, the risk of MS increased with the increase of UA level, especially in middle-aged and elderly women. Conclusions The prevalence of HUA in Bai nationality in Dali, Yunnan Province is high. Serum and uric acid levels are associated with MS. Elevated serum uric acid is an independent risk factor for MS.