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目的 观察霉酚酸酯 (骁悉 ,MMF)在预防肾移植术后近期 (3个月 )急性排斥反应的情况。方法 选择尸肾移植患者 112例 ,随机分成两组 :MMF(2 .0 g/ d)组和硫唑嘌呤 (AZA)组 ,两组患者均同时接受相似剂量的环孢霉素 A(Cs A)和类固醇激素治疗。结果 观察 3个月 ,急性排斥发生率 ,MMF组 6 0例 ,为 16 .6 % (10 / 6 0 ) ;AZA组 5 2例 ,为 41.5 % (2 2 / 5 2 ) ;两组差异显著 (P<0 .0 1)。 MMF组 5例发现血白细胞、血小板等不同程度下降 ,3例出现腹泻 ,在 MMF减量或停药后均恢复正常 ,未见有 MMF引起的肝、肾功能异常病例 ;AZA组有 9例出现肝功能损害。结论 MMF具有预防和减少近期急性排斥反应效果 ,且副作用轻 ,为可逆性。
Objective To observe the recent (3 months) acute rejection of mycophenolate mofetil (MMF) in the prevention of renal allograft transplantation. Methods One hundred and twelve patients with corpse renal transplantation were randomly divided into two groups: MMF (2.0 g / d) and azathioprine (AZA). Both groups received concurrent doses of cyclosporine A ) And steroid treatment. Results The incidence of acute rejection at 3 months was 60% in MMF group and 16.6% (10/60) in MMF group, 41.5% (2 2/5 2) in AZA group, with significant difference between the two groups (P <0. 01). MMF group of 5 patients found different levels of white blood cells, platelets decreased, 3 cases of diarrhea, MMF reduction or withdrawal were back to normal, no MMF caused liver and kidney dysfunction cases; AZA group of 9 patients Liver damage. Conclusion MMF has the effect of preventing and reducing the recent acute rejection, with mild side effects and reversibility.