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硒结合蛋白1(se1enium-binding Protein1,SBP1)为含硒蛋白的家族成员之一,参与多种细胞内硒的转运,在多种恶性肿瘤中表达减少,并在恶性肿瘤的发生、发展中发挥一定的作用,近年研究发现SBP1是某些恶性肿瘤的预后相关因素,将很有可能成为新的肿瘤预防和筛查的标志物.该文旨在探讨SBP1与肿瘤发生、发展以及预后等的关系,并阐述其可能的抗肿瘤机制,为进一步研究SBP1与肿瘤的关系提供思路.“,”Se1enium-binding Protein 1 (SBP1) is one of the fami1y members of se1enoProteins. It invo1ves in the transPort of se1eni-um in a variety of ce11s, and P1ays a certain ro1e in the occurrence and deve1oPment of ma1ignant tumors. The exPression of SBP1 is in a 1ow 1eve1 in a variety of ma1ignant tumors. Recent studies have found that SBP1 may be a Prognostic factor in some cancers, so it is exPected to become a new target for cancer contro1 and screening. This artic1e aimed to exP1ore the re1ationshiP between SBP1 and oc-currence, deve1oPment and Prognosis of tumor, exP1ain Possib1e anti-tumor mechanisms, and Provide ideas for further study.