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目的:了解该地区女性生殖道支原体感染及其临床药敏情况,为合理规范化诊治本地区生殖道支原体感染提供依据。方法:选取2006年1月~2007年5月来枣阳市妇幼保健院妇科门诊就诊的女性生殖道感染患者760例,进行宫颈分泌物支原体培养,并对阳性标本做10种抗生素药敏试验,采用支原体培养、鉴定、药敏一体化试剂盒进行检测。结果:760例女性生殖道感染患者中支原体阳性为468例,感染率为61.58%,其中解脲支原体(UU)、人型支原体(MH)及混合感染(UU+MH)的阳性率分别为54.21%(412例)、1.97%(15例)及5.39%(41例)。药物敏感情况:单一UU感染前3位为交沙霉素88.83%(366/412)、强力霉素86.89%(358/412)、美满霉素77.91%(321/412);单一MH感染前3位的为交沙霉素80.00%(12/15)、强力霉素和美满霉素73.33%(11/15);UU+MH混合感染前3位为强力霉素58.54%(24/41)、交沙霉素46.34%(19/41)、克拉霉素及美满霉素43.90%(18/41)。耐药性测定结果:单一UU感染耐药性最高的为环丙沙星57.77%(238/412),单一MH感染耐药性最高的为罗红霉素80.00%(12/15),UU+MH混合感染耐药性最高的为氧氟沙星70.73%(29/41)。结论:该研究中女性生殖道支原体感染率为61.58%,主要以UU感染为主。交沙霉素、强力霉素、美满霉素是治疗本地区支原体感染的首选药。
Objective: To understand the prevalence of Mycoplasma genitalium infection and its clinical susceptibility in this area and provide the basis for rational and standardized diagnosis and treatment of genital Mycoplasma infection in this area. Methods: From January 2006 to May 2007, 760 cases of female genital tract infection in gynecology clinic of MCH hospital of Zaoyang City were selected for culture of mycoplasma of cervical secretions, and 10 antibiotic susceptibility tests were performed on positive specimens. Mycoplasma culture, identification, drug sensitivity integration kit for testing. Results: The positive rate of mycoplasma in 760 female patients with genital tract infection was 468 and the infection rate was 61.58%. The positive rates of UU, MH, and UU + MH were 54.21 % (412 cases), 1.97% (15 cases) and 5.39% (41 cases). In the first three cases of single UU infection, 88.83% (366/412) were josamycin, 86.89% (358/412) for doxycycline and 77.91% (321/412) for minocycline. (12/15), doxycycline and minocycline 73.33% (11/15) respectively. The first three spots of mixed infection with UU + MH were 58.54% (24/41) of doxycycline, Josamycin 46.34% (19/41), clarithromycin and minocycline 43.90% (18/41). The results of drug resistance test showed that the highest drug resistance of single UU infection was 57.77% (238/412) of ciprofloxacin, the highest drug resistance of single MH infection was roasted erythromycin 80.00% (12/15), UU + The most resistant to MH infection was ofloxacin (70.73%) (29/41). Conclusion: The prevalence of mycoplasma in female genital tract in this study was 61.58%, mainly UU infection. Josamycin, doxycycline, minocycline is the treatment of mycoplasma infection in the region preferred drugs.