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饮酒妇女所生婴儿常有某些特殊缺损,称胎儿乙醇综合征(FAS)且死产发生率亦高,围产儿死亡率比不饮酒妇女高10倍。在对人和动物实验的研究中,乙醇在胎生期何时影响胎儿使其发育改变尚未有详细说明。FAS的主要表现为宫内和产后生长迟缓、头颅变小、中枢神经系统功能异常及颅面部形态异常。典型的面部特征为额部狭窄、面颊扁平、睑裂狭小、鼻短、上唇长唇红,缘扁薄和人中表浅或消失。作者对小鼠在妊娠7天时用2个小剂量乙醇(25%乙醇0.015ml/g体重)间隔4小时注入腹腔内。对照组用不含乙醇的液体作同样注射。应用极精密的气体色谱法检测血液内乙醇浓度,最高值(193～215mg/dl)出现在每次注射后20～25分
Women born to alcoholic women often have some special defects, called fetus alcohol syndrome (FAS) and the incidence of stillbirth is also high, perinatal mortality 10 times higher than non-drinking women. In studies of human and animal experiments, it has not been elaborated when ethanol affects the fetus in its lifetime to make its developmental changes. The main manifestations of FAS intrauterine and postpartum growth retardation, smaller skull, central nervous system dysfunction and abnormal craniofacial morphology. Typical facial features are narrow forehead, flat cheeks, narrow palpebral fissure, short nose, long lip with long lip, thin edge and thin or superficial appearance. The mice were injected intraperitoneally with 2 small doses of ethanol (25% ethanol 0.015 ml / g body weight) for 4 hours at 7 days gestation. The control group was injected with the same ethanol-free liquid. The use of very precise gas chromatography to detect blood ethanol concentration, the highest value (193 ~ 215mg / dl) occurs after each injection of 20 to 25 minutes