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作者对25例应用PUVA治疗的银屑病患者进行研究,观察PUVA对朗格罕氏细胞的影响.结果,发现朗格罕氏细胞数量和形态方面均有明显改变.在数量方面,在PUVA治疗前,平均密度为730/mm~2,而在治疗3次(1周)后,则减少到300±28/mm~2,7次后减少到56±29/mm~2.继续治疗,除3例病人由于皮肤色素加深,朗格罕氏细胞略有回升外,其余仍维持低水平.在形态方面,早期(甚至仅一次照射后)即可见树状突减少,治疗2～3周
The authors studied 25 patients with psoriasis treated with PUVA and observed the effect of PUVA on Langerhans cells.Results, the number and morphology of Langerhans cells were significantly changed.In quantity, in the PUVA treatment Before the average density of 730 / mm ~ 2, and in the treatment of 3 times (1 week), then reduced to 300 ± 28 / mm ~ 2,7 times reduced to 56 ± 29 / mm ~ 2. Continued treatment, except In 3 patients, the Langerhans cells slightly recovered due to the deepening of the skin pigment, while the remaining remained low. In terms of morphology, dendrites decreased in the early stage (even after only one irradiation), and the treatment period was 2 to 3 weeks