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为了探讨人巨细胞病毒（ｈｕｍａｎｃｙｔｏｍｅｇａｌｏｖｉｒｕｓ，ＨＣＭＶ）与宫颈癌发生之间的关系，我们利用紫外线灭活的ＨＣＭＶ诱发小鼠宫颈癌的动物模型进行了研究．经ＵＶ－灭活的ＨＣＭＶ液接种于小鼠宫颈部，３次／周×８周，并设ＨＥＬ培养液对照组．５个月后，ＨＣＭＶ组宫颈癌前病变率达２７．７％（２３／８３），癌发率２０．５％（１７／８３）；对照组仅１例发生宫颈内皮瘤（ＣＩＮ，Ｉ），癌发率为０（０／３１）．此结果提示：紫外线灭活的ＨＣＭＶ具有在体内转化宫颈上皮细胞，从而诱发宫颈癌发生的能力，因而也讨论了ＨＣＭＶ致癌的可能机制．
In order to investigate the relationship between human cytomegalovirus (HCMV) and cervical cancer, we studied the mouse model of cervical cancer induced by UV-inactivated HCMV. The UV-inactivated HCMV solution was inoculated into the cervix of mice, 3 times / week × 8 weeks, and HEL culture medium control group was established. After 5 months, the rate of cervical precancerous lesions in HCMV group was 27.7% (23/83) and the incidence of cervical cancer was 20.5% (17/83). In control group, only 1 case had cervical intraepithelial neoplasia (CIN, I) , The incidence of cancer was 0 (0/31). This result suggests that: UV-inactivated HCMV has the ability to transform cervical epithelial cells in vivo to induce cervical carcinogenesis and therefore the possible mechanism of HCMV carcinogenesis is also discussed.