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抑制肿瘤的生长、转移一直是肿瘤治疗的关键。而肿瘤均具有血管形成依赖性。直径1～2mm以内的肿瘤组织能通过渗透吸收营养。随着肿瘤细胞数量的增加(10~6个细胞以上)、瘤灶的长大,必须依赖肿瘤局部血管的新生。新生的肿瘤血管是肿瘤快速生长的物质和形态学基础,也是肿瘤细胞迁移游走、进入循环、形成转移的必经之路。机体血管形成的“开关”是由细胞分泌的激活剂和抑制剂的平衡而定。激活剂包括生长因子、转化生长因子、血管内皮生长因子、单核因子等;而抑制剂包括血管内皮抑素、内皮抑素等。由于肿瘤是机体发育过程中生长控制紊乱
Inhibiting tumor growth and metastasis has been the key to cancer treatment. The tumors are vascular-dependent. Tumor tissues within 1 to 2 mm in diameter can absorb nutrients through penetration. With the increase in the number of tumor cells (10 to 6 cells or more) and the growth of tumor foci, we must rely on the angiogenesis of local tumors. Newborn tumor vessels are the material and morphological basis for the rapid growth of tumors, and they are also the only way for tumor cells to migrate away, enter circulation, and form metastases. The “switch” of blood vessel formation in the body is determined by the balance of activators and inhibitors secreted by the cells. The activators include growth factors, transforming growth factors, vascular endothelial growth factors, monocytes, and the like; and the inhibitors include endostatin, endostatin, and the like. Because the tumor is a disorder of growth control during the development of the body