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神经母细胞瘤是儿童期较为常见的肿瘤之一。其发病率仅次于白血病、淋巴瘤以及中枢神经系统肿瘤。Cox等(1965)发现神经母细胞瘤患者肿瘤细胞中出现一种成对排列的微小染色体——双微小染色体(Minute chromatin bcdies)。Sandberg等也在1例神经母细胞瘤
Neuroblastoma is one of the more common childhood tumors. Its incidence is second only to leukemia, lymphoma and central nervous system tumors. Cox et al. (1965) found that a pair of tiny chromosomally arranged chromosomes (Minute chromatin bcdies) appeared in the tumor cells of patients with neuroblastoma. Sandberg et al are also one neuroblastoma