论文部分内容阅读
目的评价早产儿胎盘组织炎症反应程度及其病程进展对早产儿脑室内出血发病风险的影响。方法收集2008年3月至2009年9月三所医院分娩的493例早产儿临床资料,对其胎盘组织绒毛膜羊膜炎症反应进行分级分期,利用头颅B超、CT和MRI等影像学手段对脑室内出血诊断并分级。结果产妇绒毛膜羊膜炎患病率为30.0%(148/493),早产儿脑室内出血患病率为20.9%(103/493)。在校正了早产儿胎龄、性别、体重、胎膜早破以及分娩方式等因素后,胎盘Ⅱ级和Ⅲ级炎症,以及胎盘Ⅱ期和Ⅲ期炎症分别是早产儿脑室内出血的独立危险因素,其比值比分别为1.33(95%CI:1.02～1.87),2.01(95%CI:1.54～2.73),1.33(95%CI:1.02～1.87)和2.01(95%CI:1.54～2.73)。结论早产儿胎盘绒毛膜羊膜炎组织病理不同分期、分级与早产儿脑室内出血患病风险密切相关。
Objective To evaluate the influence of placental inflammatory response in preterm infants and its progression on the risk of intraventricular hemorrhage in premature infants. Methods The clinical data of 493 preterm infants delivered from March 2008 to September 2009 in our hospital were collected. The chorioallantoic membrane inflammatory reaction in the placenta was graded and staged. The brain ventricle Internal bleeding diagnosis and grading. Results The prevalence of chorioamnionitis was 30.0% (148/493), and the prevalence of intraventricular hemorrhage in preterm infants was 20.9% (103/493). After adjusting for such factors as gestational age, gender, weight, premature rupture of membranes and mode of delivery, placental grade II and III inflammation and placental stage II and III inflammation were independent risk factors for intraventricular hemorrhage in preterm infants, respectively. The odds ratios were 1.33 (95% CI: 1.02-1.87), 2.01 (95% CI: 1.54-2.73), 1.33 (95% CI: 1.02-1.87) and 2.01 (95% CI: 1.54-2.73), respectively. Conclusion The histological and histological changes of placental chorioamnionitis in preterm infants are closely related to the risk of intraventricular hemorrhage in preterm infants.