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目的 :探讨转化生长因子 (TGF) β1、CD4 4V6、bcl 2及p5 3蛋白在喉鳞状细胞癌中的表达与喉鳞状细胞癌患者的病理分级、临床分期和患者生存率间的相互关系 ,以研究TGF β1在喉鳞状细胞癌发病机制中的作用。方法 :利用免疫组织化学法测定 4 3例喉鳞状细胞癌石蜡切片中TGF β1、CD4 4V6、bcl 2及 p5 3蛋白的表达。结果 :TGF β1在病理Ⅰ、Ⅱ、Ⅲ级中阳性表达率分别为 86 .96 %、82 .35 %和 10 0 .0 0 % ;CD4 4V6分别为 6 0 .87%、70 .5 9%和 10 0 .0 0 % ;bcl 2分别为 82 .6 1%、94 .12 %和 10 0 .0 0 % ;p5 3分别为 2 6 .0 9%、35 .2 9%和 6 6 .6 7%。 结论 :①TGF β1表达与喉鳞状细胞癌的病理分级、临床分期、颈淋巴结转移和患者的 3、5年生存率有关 ,可作为评定喉鳞状细胞癌的进展、预测其转移与预后的指标。②TGF β1在喉鳞状细胞癌中的表达与CD4 4V6、bcl 2、p5 3具有一定的相关性。
Objective: To investigate the relationship between the expression of transforming growth factor (TGF) β1, CD4 4V6, bcl2 and p5 3 in laryngeal squamous cell carcinoma and the pathological grade, clinical stage and survival rate of patients with laryngeal squamous cell carcinoma In order to study the role of TGFβ1 in the pathogenesis of laryngeal squamous cell carcinoma. Methods: The expressions of TGF β1, CD4 4V6, bcl 2 and p5 3 in paraffin sections of 43 laryngeal squamous cell carcinomas were detected by immunohistochemistry. Results: The positive expression rates of TGF β1 in pathological grades Ⅰ, Ⅱ and Ⅲ were 86.96%, 82.35% and 100.0% respectively. CD4 4V6 was 60.77% and 70.59% And 100.0% respectively; bcl 2 was 82.61%, 94.12% and 100.0% respectively; p5 3 was 26.0%, 35.29% and 66%, respectively. 6 7%. Conclusion: ① The expression of TGFβ1 is correlated with the pathological grade, clinical stage, cervical lymph node metastasis and 3-year and 5-year survival rate of laryngeal squamous cell carcinoma, which can be used as the assessment of laryngeal squamous cell carcinoma and predict its metastasis and prognosis . ② The expression of TGFβ1 in laryngeal squamous cell carcinoma has a certain correlation with CD4 4V6, bcl 2 and p5 3.