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目的 :探讨影响鼻咽癌病人受损颅神经恢复的相关因素。方法 :1989年 1月至 1991年 1月我科收治鼻咽癌伴颅神经受损病人 12 8例 ,共 2 45条颅神经受损。对影响受损颅神经功能恢复的可能因素进行单因素及多因素 Cox模型分析。结果 :放疗后 1年内受损颅神经中有 6 5 .7% (16 1/ 2 45 )完全恢复 ,19.2 % (47/ 2 45 )部分恢复 ,15 .1% (37/ 2 45 )无变化 ,总的有效率为 84.9% (2 0 8/ 2 45 )。单因素分析结果 :颅神经功能开始恢复时间、颅神经损伤症状期、前后组颅神经、颅底破坏、临床分期 5个因素明显影响颅神经功能恢复 ,差异有显著性意义 (P <0 .0 5 )。 Cox多因素分析结果 :颅神经功能开始恢复时间、损伤症状期明显影响颅神经功能恢复 ,差异有显著性意义 (P <0 .0 5 )。结论 :颅神经功能开始恢复时间短、损伤症状期短 ,则恢复效果好。
Objective: To explore the factors that affect the recovery of damaged cranial nerves in patients with nasopharyngeal carcinoma. Methods: From January 1989 to January 1991, 128 cases of nasopharyngeal carcinoma with cranial nerve injury were treated in our department. A total of 2 45 cranial nerves were impaired. Univariate and multivariate Cox models were used to analyze the possible factors influencing the recovery of the damaged cranial nerves. Results: In one year after radiotherapy, 65.7% (16/1/245) of the damaged cranial nerves recovered completely, 19.2% (47/245) partially recovered and 15.1% (37/245) showed no change , The total effective rate was 84.9% (208/455). Univariate analysis showed that cranial nerve function recovery time, cranial nerve injury symptoms, cranial nerves in the anterior and posterior group, skull base destruction and clinical stage significantly affected cranial nerve function recovery, the difference was significant (P <0. 0 5). Cox multivariate analysis showed that cranial nerve function began to recover, and the injury symptoms significantly affected cranial nerve function recovery, the difference was significant (P <0.05). Conclusion: The recovery time of cranial nerve function is short and the symptom of injury is short, the recovery effect is good.