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目的:观察慢性心功能不全(CHF)患者血清甲状腺激素水平的变化,探讨其与CHF的关系。方法:用化学发光法测定120例心功能Ⅱ～Ⅳ级患者(心衰组),70例心功能正常患者(对照组)血清甲状腺激素(游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、总三碘甲状腺原氨酸(T3)、总甲状腺素(T4)、促甲状腺素(TSH)水平及左心室射血分数(LVEF),并进行比较分析。结果:心衰组患者血清FT3、T3、T4、LVEF水平明显低于对照组,FT3、FT4、T3、T4在心功能达Ⅲ～Ⅳ级时明显降低,且与LVEF相关,差异有统计学意义(P<0.01)。结论:甲状腺功能正常性病变综合征(SES)的发生率与心功能分级有关,心衰越严重,降低越明显,甲状腺激素水平的变化可评估CHF的程度,对心功能患者病情及预后判断均有价值。
Objective: To observe the changes of serum thyroid hormones in patients with chronic heart failure (CHF) and to explore its relationship with CHF. Methods: The levels of serum thyroid hormones (free triiodothyronine (FT3), free thyroxine (FT3) and thyroid hormones were measured by chemiluminescence method in 120 patients with heart failure class Ⅱ ~ Ⅳ and 70 normal heart patients (control group) (FT4), total triiodothyronine (T3), total thyroxine (T4), thyroid-stimulating hormone (TSH) and left ventricular ejection fraction (LVEF) were measured and compared.Results: The levels of FT3, T3, T4 and LVEF in serum were significantly lower than those in the control group, while FT3, FT4, T3 and T4 were significantly lower in patients with heart function Ⅲ ~ Ⅳ, and were correlated with LVEF (P <0.01). : The incidence of thyroid dysfunction syndrome (SES) and the classification of cardiac function, the more severe heart failure, the more obvious decrease in thyroid hormone levels can assess the extent of CHF, the severity of the patients with heart function and prognosis have value.