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目的观察静注人免疫球蛋白(IVIG)联合安宫牛黄丸治疗儿童2期EV71感染手足口病的疗效。方法 120例2期肠道病毒71型(EV71)感染手足口病患儿,随机分为观察组与对照组,各60例。观察组静脉给予静注人免疫球蛋白联合安宫牛黄丸,对照组单用静注人免疫球蛋白。对2期EV71感染的手足口病所表现的发热和感染均应用布洛芬和阿奇霉素,其他如皮肤溃烂等均对症治疗。比较临床体征和症状的改善情况。结果观察组临床主要症状及体征消失时间显著短于对照组,趋于3、4期发生率、病死率低于对照组,差异具有统计学意义(P<0.05)。结论静注人免疫球蛋白联合安宫牛黄丸治疗2期EV71感染手足口病效果更好,值得临床推广。
Objective To observe the curative effect of intravenous immunoglobulin (IVIG) combined with Angong Niuhuang Wan on EV71 infection in children with hand-foot-mouth disease. Methods 120 cases of enterovirus 71 (EV71) infected HFMD were randomly divided into observation group and control group, with 60 cases in each group. The observation group intravenous injection of intravenous immunoglobulin combined Angongniuhuang Wan, control group, single intravenous immunoglobulin. The EV71 infection of hand, foot and mouth disease manifestations of fever and infection are used ibuprofen and azithromycin, other such as skin ulcers are symptomatic treatment. Compare clinical signs and symptoms improvement. Results The main clinical symptoms and disappearance of signs in the observation group were significantly shorter than those in the control group. The incidence rate of the patients in the observation group was lower in the third and fourth trimester than in the control group. The difference was statistically significant (P <0.05). Conclusion Intravenous human immunoglobulin combined with Angong Niuhuang Wan 2 EV71 infection of hand, foot and mouth disease is better, worthy of clinical promotion.