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目的非甾体类抗炎药物(Nonsteroidal anti-inflammatory drugs,NSAIDs)可以预防或降低消化系肿瘤的发病率,提示环氧合酶-2(Cy clooxygenase-2,COX-2)的表达与消化系肿瘤的发生、发展密切相关,但COX-2与胰腺癌关系的报道甚少。本研究通过检测胰腺癌组织中COX-2表达,探讨COX-2与Bcl-2表达的关系,及其在胰腺癌发生发展过程中的作用。方法胰腺癌等组织COX-2和Bcl-2的表达采用ABC免疫组化分析;评价二者表达及其与患者临床病理特征关系。结果胰腺癌组织COX-2和Bcl-2的表达阳性率分别为73.3%和66.7%,阳性率明显高于胰腺良性疾病和正常胰腺组织。两者呈高度正相关,相关系数0.470(P<0.01)。但COX-2表达率与患者临床病理特征无关(P>0.05)。结论胰腺癌组织中COX-2表达增强,COX-2表达与Bcl-2表达有协同效应,共同参与胰腺癌细胞凋亡的调控。
Objective Nonsteroidal anti-inflammatory drugs (NSAIDs) can prevent or reduce the incidence of gastrointestinal tumors, suggesting that cyclooxygenase-2 (COX-2) expression and digestive system Tumor occurrence and development are closely related, but the relationship between COX-2 and pancreatic cancer is rarely reported. In this study, we examined the expression of COX-2 in pancreatic cancer and the relationship between COX-2 and Bcl-2 expression and its role in the development of pancreatic cancer. Methods The expressions of COX-2 and Bcl-2 in pancreatic cancer and other tissues were analyzed by ABC immunohistochemistry. The expression of COX-2 and Bcl-2 in pancreatic cancer tissues was evaluated and their relationship with clinicopathological features was evaluated. Results The positive rates of COX-2 and Bcl-2 expression in pancreatic cancer tissues were 73.3% and 66.7%, respectively. The positive rates of COX-2 and Bcl-2 were significantly higher than those in benign pancreatic diseases and normal pancreatic tissues. The two were highly correlated, with a correlation coefficient of 0.470 (P <0.01). However, the COX-2 expression rate had no correlation with the clinicopathological features (P> 0.05). Conclusions The expression of COX-2 in pancreatic cancer tissue is enhanced, and the expression of COX-2 and Bcl-2 have a synergistic effect, and they are involved in the regulation of pancreatic cancer cell apoptosis.